I'm a lefty as well I have owned most of them at one time or another, I favor Remingtons as I have been going the custom route as of late. That said I like the new LH Tikka T3 they have introduced; light, nice handling and every one I have dealt with has been accurate out of the box. The savages with AT are pretty darn good as well, if you don't mind an internal box mag and the feel of their tupperware stock. Ruger M77(laminate or walnut), Browning(walnut or syth. stocks available in the Abolt II line up), Rem CDL and BDL. Other ones are Weatherby Accumark V's , Sako 75 and winchester M70 (more spendy usually). The other routes are Semi Autos, Pumps and single shots(Ruger #1/TC Encore/etc).
As far as cartridge - 25-06 rem is a great deer down cartridge, this is one of my most shot cartridges(great paper puncher pleasant to shoot and very) accurate and it works great on varmits right up to big mulies. Though U can't go wrong with a .270, 7mm 08, .308 or 3006 either. 270win, 308win and 3006 sprg over the counter ammo can be found near everywhere - if that is a concern to your situation.