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I use Speer 100 gr spitzers over 51 gr IMR 4350. Found them to be more accurate than the 100 gr Nosler Partitions. Does mule deer and smaller things decisively.
The best load I've used so far is with the Sierra 117gr Spitzer BT with either 48grs of IMR 4350 or 50grs of IMR 4831. Got a three shot group of 0.486", shot at 185yds.
Best load ever for me is 55 gr. IMR 7828 under 120 Nosler Partition and 120 gr. Hornaday Spitzer. Federal 215 primer. Muzzle velocity is 3280 out of a Ruger 1B with a 26" bbl., and accuracy is very good indeed.
I loaded for a Brno ZKK 600 with a 24" Remington bbl. for years before this and couldn't come even close velocity-wise using H4831, Norma MRP, Reloader 22 or a compression load of H870. Accuracy is/was about the same in both rifles, and so far case life has been exceptional.