The gun came with some bullets, they weigh 255grns. So I
Figure they are suppose to be 260grn they are .455 round nose flat base. Can I start out with 4grns of unique and go up to 5 max? I probably won't go that high. Thanks!
Yeah I know those bullets. They are originally from ben Hunchak. They are Lyman 454190 cast 30-1. They shoot well in that revolver, too.

But there's a couple things to be careful with using those bullets in a MKII Hornady .455 cartridge, which is what I assume you are using.
Because the Webley MKII cartridge is so very short, it is easy to seat the bullet too deeply and greatly increase pressure. Small differences in bullet seating depth tends to have drastic effects on pressure in the MKII cartridge. (Don't confuse the Webley .455 MKII cartridge with the Webley MKII revolver, one is a gun and one is ammunition, it can be confusing).
Using 4.0 gr Unique with the Lyman 454190 bullet seated with both grooves inside the case should be OK according to Quickload, but don't seat it any deeper than you have to. Unique is a very good powder but it is not as forgiving as some other powders and pressure spikes can be induced fairly easily.
The webley MKI/II pistols were designed for a cartridge producing approximately 13,000 psi maximum pressure. Quickload estimates that using 4.5 gr Unique and the lyman 454190 bullet seated with both lube grooves inside the case will cause a pressure spike and bump pressure to well over 20,000 psi. QL estimates the same load with this bullet seated so 1 groove is outside the case mouth drops back to about 12K psi again. In my experience Quickload tends to slightly overestimate pressure with small capacity cartridges but the trend will be accurate and i have no doubt that the spike is there if you push it.
The HB bullets have a built-in safety factor in that the HB provides extra case volume.
Load data is not interchangeable between Webley MKII cartridges and .45acp cartridges used in webley revolvers.
I hope that makes sense, if not ask or PM and I will try to explain it better.