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Blue can be a little too much to break loose on #size screws.
And red, you might as well just weld the screw in. Not the best idea for anything aluminum or smaller bolts that 3/4". And you need to heat it up to 300deg or so.
Right from Loctite's website
"For years, gunsmiths have turned to Loctite for securing screws and other threaded parts on their projects. Each formula has unique features that make it perfect for various applications around the shop. Purple Threadlocker (222) is for use on set screws, calibration screws, meters and gauges. This non-wicking formula is recommended for fasteners from #2 through 1/4" and cures in 10 minutes with full strength in 24 hours. This threadlocker is low strength and requires only handtools to remove once applied."