FWIW, the standard Wimbledon Cup .300 Winchester Magnum load for years used something like 68.5 to 69 grains of IMR 4350 with a 190 Sierra. This normally produces speeds of around 2,900 with match barrels.
The Nosler reloading manuals are excellent, but Nosler seems to be a bit optimistic in their velocity figures -- by about 100 fps or so.
According to my Nosler Manual, 70.0 grains of IMR 4350 is listed as the most accurate load with that powder and a 180 Partition. In the real world, that should be getting you about 2,950 to 3,000 -- just about perfect.
You are correct that there will not be any practical difference between the top and bottom loads with that bullet out to 300 yards. Frankly, a .308 with a 180-grain bullet can do the job on a moose at 300 yards, so you will be fine whatever load you choose.
I think you should load up 10 rounds each of your top and bottom loads and shoot a 10-round group at 200 metres, taking LOTS of time to pace out your shots over a couple of hours.
I would choose whichever load is the most consistent and accurate and stay with it.
You talk about "comfort vs. speed". Frankly, there won't be much recoil difference between the top and bottom loads that you have listed. As to speed, I would expect that 4 grains less IMR 4350 will probably lose you around 150 fps. If your top load is, say, 2,975, then your bottom load will be about 2,825, give or take. Probably not enough to worry about -- even for shooting longer than 300 yards. For these reasons, go with the load that is most consistent and accurate and forget about the rest.