A bolt action .375 H&H is a fine rifle for the client going to Africa. It is also the most common rifle clients take because it is accurate, versatile, effective, and shooter friendly. I would tell your pal to look into a rifle with a control round feed action, such as the Brno, Ruger, or a Winchester M-70 Classic if he can find one. It should be topped of with a fixed low power or medium power variable scope. I would suggest he take a second scope in case of damage. He will likely have the opportunity to take plains game which may weigh as little as 20 pounds or as much as a ton. The .375 will work well for both without the explosive results normally associated with high velocity rifles. Some PH's will want him to have both soft points and solids, but he can probably do everything with 300 gr TSX's, and simplify his logistics.
He will need to get permits for his rifle from every country he transits - including the United States. These in transit permits should be acquired well in advance, and can be applied for from the consulates of the countries in question. The country he is hunting in might have a tax for importing a rifle into the country - Tanzania was $200 USD. The currency of choice is USD, and he should carry lots of small bills for tips.
If you would like more information, PM me with your email address. We hunted the Selous Game Reserve last summer.