Well, it depends what cartridge you're shooting and which weight of bullet you choose. In my .30/06 rifles with both 1:10 and 1:12 twists, the 180 gr TSXs shoot well, but neither liked the old 200 gr X. In the 7X57 and 7-08, with 1:9s, the 140s are dynamite. I thought I'd be alright with a 1:14 twist .22-250 and the 53 gr TSX, but that one didn't stabilize, and I never had the opportunity to try a lighter bullet; it wasn't my rifle. The 85 gr TSX shot well in my 1:10 .243. I haven't had any stability issue with any weight of TSX in the 1:12 .375 although I haven't tried the 350 gr version, and believe it would be best in a .378 Weatherby. While I only used the first generation 350 gr X bullet and the 400 gr mono solid in the .416 Rigby, there were no problems.