I Personally use only 250's (hornady interlock) and occasionally 225 (Interbonds)
Or interlocks. (I don't worry too much about bullet failure in a 250 grain bullet, as a 100 grain bullet can put a moose down, If it busts into pieces, which is not likely at speeds in the .30-06 neighborhood, will still take down a bull)
Reloader 19 seems to be my go-to powder , along with reloader 22.
---For the 225 X bullet, I use 71 grains of RL19 in Winchester brass, over a Magnum primer (winchester) with a good crimp.Minimum O.A.Length is 3.335"
It averaged 2730 Ft/Sec over my chrony.
---For the 225 interbond/interlock, I use 73.8 gr of Rel 19 (same brass/primer/crimp) for an average of 2801 f/s Minimum O.A.Length is 3.33 inches
---For the 250 Interlocks (or other pointed cup/core bullets) I used 72.5gr of Rel 19 (compressed slightly) (win brass/win magnum primer) Minimum O.A.Length 3.33"
This ones averages 2695 F/S and its my most accurate load. I punched several 0.6" groups last summer at the range, (but let me tell you, my lead sled sure takes the beating out of a shooting session.)
I suggest you start with a powder charge 5% or more lower, as these were loads I worked up in my Ruger Mk II , and they were all about 90% or more before the books said Max. There was slight room for my loads to go up a bit, but I noticed some primer flattening with loads .5-1 grain larger. So , for my gun, these are "Max" loads. Always load for accuracy, not max velocity. Sometimes they are the same thing, but not too often.