It all depends on your disposition? It doesn't save much less to reload the larger full size calibers than it does to buy ready to fire MFS loads. If you're match shooting you will want to load your own, but if you just plink away and they work fine for hunting, then why bother? the difference between the two is the cost of brass.
For 5.56 and other small rounds, I just buy bulk. I can't be bothered to reload for small cases and I don't have the time of day to do it.