People are beating this subject to death for very little reason. It's comparable to counting the hairs in a gnat's butt to see which one has better flight control.
For the average hand loader that is happy with 1.5 moa groups out to 300 meters component changes often don't make any difference to their happy mode.
For those of us that are a bit anal about accuracy, component lot batches can make a significant difference.
Bullets, cases, powders, primers are not created equal between lots. Truth be told, they're not always equal within the same lot for several reasons.
Most of these differences are not within our or the manufacturers ability to control, other than to keep them within specified plus or minus parameters of their median control figures.
The only REAL way to keep relatively consistent accuracy/velocity results is to purchase large quantities of the SAME LOT NUMBER components.
The folks that purchase 100 counts, primers/bullets and a single pound of powder at each purchase, have to start over with load development every time they replenish their stocks.
One way to get around this with powder, is to take several containers of the SAME MANUFACTURER and SAME DESIGNATION and blend them together. This will give you ONE LARGE LOT of powder with a consistent burn rate. YES, IT'S SAFE TO DO THIS as long as you aren't mixing different types of powder, such as mixing W748 with CF223. Mixing W748 with another lot of W748 IS SAFE.
Sadly, you can't do the same with bullets/cases/primers. Luckily with modern manufacturing techniques, bullets are now far more consistent from lot to lot than I've seen over fifty years of shooting.
Back in the 70s, four MOA groups were considered to be acceptable. Now, components are so good 2 MOA is the norm.