When escalating to this level of detail, one should use benchrest or match grade primers as opposed to standard primers, the extra cost in these primers is due to more attention to loading a smaller and more uniform priming charge.
Last year I switched from standard to match primers and deburred flash holes (Winchester brass) in my .308 tactical rifle (changed nothing else) and that shrunk my 100 yd group size from 3/4" to 1/2". Ignition consistency is primary in the group size game. I throw all my powder charges, and I have yet to optimize the charge weight for this combo.......next season.