I have loaded and fired 10s of thousands of 357 and I use exclusively H110/W-W 296 and CCI 550 spm primers and a heavy crimp into the cannelure. I even trimmed all my 357 once upon a time when I was shooting some silhouette with it, in order to get a good firm and consistent crimp on my bullets. I moved up to a 44 mag after but followed all the same procedures and I got very consistent loads by doing this. I have seen a dirty ugly squib with 296 and a standard primer with no crimp. It is an ugly and stinky thing, one must also then remove the bullet from the barrel and scrape all the goo, which turns to a glass like substance when it cools and is a nightmare to remove from your pistol.
Virtually every manual recommends a magnum primer when using H110/296 and there is a good reason for it, it is also the "go to" powder if you truly want absolute maximum magnum loads. I have never used a magnum primer with any other powder in any pistol, but I have never tried L'il Gun in a pistol cartridge but I suspect given it's shape and burn rate a magnum primer may well be a good idea.