I have a 550b and reload .223 in three different loads. I use the powder feed for one (for general plinking) and a modified funnel system for doing the other two (running two different tip types with the same Point of Impact so I hand measure these bad boys). I have never had a real problem with either using a competition Dillon 3 die set-up (deprime & size, powder fill & flair, bullet seat & de-flair). The .223 base kit (disc, pins, funnel & flair) comes with size 3 casing retention pins that are a hair loose on the cases and if you try a "speed of blue-blazing hell" reloading method you can damage a case if it hits the powder funnel holding die; but I have seen that problem with other sizes between my friends and myself, including 9mm and .357 Sig...
I have tried quite a few powders and use two different ones now with no problems.
Otherwise, I have thousands of .223 through my 550B...