Yes, I have played around with a single shot 30-30 loading different bullets. A 180g Hornady interlock round nose will not always open up sufficiently at over 100 yards. This would be the same velocity as a 30-06 at 300 yards.
If you check the Hornady manual you will find they do not recommend the bullet at a muzzle velocity of less than 2400fps.
If you section that same bullet you will find that it has a thicker than normal jacket. This is true of many round nose bullets. Round nose bullets open easier due to the front shape, this allows a thicker jacket than normal to be used and still have expansion. That thicker jacket does retard expansion and increase penetration. This is why round nose were so popular 50 years ago.
Bottom line, stick with 30-30 bullets for your 30-30 for hunting. That way you can be 100% sure they were designed for that velocity range.
I don't know about the Remington round nose bullets. The only one I have sectioned was the 180g bullet for the 303. It had a thicker than normal jacket but much better frontal "petals" cut in for expansion. The old Remington round noses had a very good reputation at one time for penetration.