Remmy700, if you're using late manufacture powders that Lyman #50 should cover just about everything, other than the older obsolete or military cartridges. The new #51, which I haven't seen for sale will have a bit more information on the powders mostly available at the time.
Many of us older folks here have powders dating back to WWII, such as 4831, with no prefix letters. This powder was offered by Hodgdon and many other outlets, in bulk as cheap as a dollar for a 5 pound paper sack full. So we bought lifetime supplies.
That old powder has a slightly different burn rate to the later "new manufacture" powders.
If you follow standard procedures, and start with reduced loads, all is well.
This is where the older manuals really shine.
Looking at data spread sheets on reloading is fine, but I find it tedious. I like have a hard copy, book in my hands that I can compare to other books.
The reason for this is that some of the older loads would be excessive with new manufacture powders of the same designation.
If you're shooting modern or proven strong firearms, this really isn't an issue, but some get very excited over flattened primers, which are supposedly and indication of high pressures. Generally it's a great rule of thumb and really is time to drop your load by half a grain or more.
Sadly, it often happens that the sweet spot for the rifle is at the point that flattens the primers. It may just be the time to use a slightly slower powder, or even a slightly faster powder, depending on the circumstances.
The list is long when it comes to variances. Today, most cannister grade (off the shelf) powders are extremely consistent from lot to lot.
So consistent that a lot of younger hand loaders don't even bother to check their points of impact with a different lot of powder.
Back in the day, any change at all between powder lots, primer lots and of course brass lots meant that the loads had to be checked for everything from velocities to POIs.