The stock answer to this question used to be "get a good 357 magnum revolver, shoot 38's in it, when you've shot it enough to be accurate (or you just want a buzz) shoot 357's." It's good advice. 38 is probably the easiest and cheapest calibre to reload (HINT HINT) with the cost of 38 reloads being not too much higher than good quality 22 lr. A decent quality revolver which can be (some would say should be) used and a reasonable quality reloading set up, components etc. can be had for reasonable prices, and will give several lifetimes of service. I put 40,000+ rounds through a Smith Model 10 after loading them on a Lee turret press (I had time, not money) The revolver worked flawlessly and the only evidence that it had a huge round count was the smooth as silk trigger pull when I sold it (I did tell the buyer how many rounds it had through it, he didn't care as the gun was clean, well taken care of and in perfect time). The nice thing about an out of the box revolver is that they are amazingly accurate, and will allow you to become a very precise shooter.