204 is a faster flatter shooting cartridge for the first couple of hundred yards. Speed is important for "style points"... It loses effectiveness beyond about 350 yards, although I have made a couple of calm condition 400-450 yard kills on gophers. I have killed coyotes with it to 350 and they were dead before they hit the ground. 204 is under-appreciated for its yote-sized varmint capabilities.
If you want to kick it up a notch, a 22-250 is a better comparison
The both make 'em dead, the 204 makes a smaller hole.