I like the Ruger Mk 2's and own one myself. (After selling the first one, and missing it...) It shoots almost as accurately as my Walther GSP and only cost about 15% of the price. (Well, at least in the used market.) Yes, the reassembly can be a little finicky. I convinced a friend of mine, a brand new shooter, to buy a Mark 3 in the .22/45 configuration, since he was all gung-ho to practise for his 1911. I think it ended up being a mistake, since putting it back together, after he took it apart for cleaning, seemed even harder than previous Rugers, and a pita because of the magazine safety and having to replace/remove several times because the instructions call for having the action fired.
So in summary: my advice is get a good used Ruger. Mrk 2. A nicely used one will have been worn in and/or had a trigger job done, and it will shoot well.
Ok, so you need a second hand to remove the mag... Well whoop-de-doo! It's just a .22 plinker, not a fast mag changing IPSC/combat/service pistol!