I like my guide gun, but if you are hand-loading you have to be aggressive. I used early data - 73 grains of powder, and it chronographed a 400 grain nosler partition at 1,950fps - down in 45-70 territory. The factory ammo (out of a 23" African barrel) books at 2,400fps, which is a lot better. Since then people have reported loads up above 78 grains (I forget the powder, and I am STILL at the office), which might give a bit more kick. Whether it'll ever chrony to book speeds, someone please tell me.
Still, I was out in grizzly country in northern BC last week (with a mag stuffed full of factory ammo) and I slept well with that gun next to me. Yeah the factory stock is probably too grippy, and I did have to spend 20 minutes with a dremel, polishing the feed ramp and feed lips, but she's butter smooth now and is more accurate than any elephant gun ever needs to be.
I like the Ruger action: controlled-round-feed and a bullet-proof three-way safety. In fact, I traded from my Remington 700 in .375H&H for the Ruger Alaskan, and never looked back.