To go a bit further - there are a number of considerations. The barrel/bolt nose clearance must be correct. This is related to shank length if the barrel has a shoulder. Then, of course, headspace from breech face to datum point in the chamber has to be right. The beauty of the Savage system, as designed by Brewer and refined by Greenleaf is that there is no barrel shoulder, the chamber can be finish reamed without an need for fitting to a specific action and boltnose/barrel clearance and headspace are guaranteed when the barrel is screwed in on gauge and the barrel nut tightened. Another significant manufacturing advantage is that the Savage system barrels can be manufactured from smaller diameter steel bars. If there is a shoulder on the barrel, a larger billet is needed. If you are making 100s of thousands of barrels the material and machine time savings are substantial. No. 4 Lee Enfields used timed barrel threads and a finished chamber, with headspace being set using boltheads of different lengths. Remington uses a similar system. Look at the left hand locking lug on a Remington bolt. It might be plain, have a dot, or a line. These denote different lengths of boltheads.
The Savage system makes the 110 action one of the most versatile for experimenters. Barrel and caliber change are easy. Unfortunately, magazine adaptation is not, outside of families of cartridges with similar lengths.