A others have stated, working up your own loads from scratch is generally not recommended. I have read and studied shotshell loading quite a lot over the years as I reload for trapshooting as well as 2.5" paper hulls for my old British guns.
As for the components, shotshell primers seem to have a wider range of "power" than rifle/pistol primers, so changes in primers can result in large pressure differences. Shotshell hulls can have widely different interior shapes - they are not just a standard straight tube. Some are tapered, some straight and dimensions vary a lot. Wads designed for one hull may be either a sloppy or too tight fit in another hull, thus changing pressures wildly. Shotshell powders (sometimes also usable as pistol powder) are fast burning, so a small difference in charge weight can give massive pressure spikes.
Invest in some shotshell reloading manuals and look carefully at the load data and how changes in components can quickly lead to problems. An extra $100 in published books is far cheaper than replacing your gun, not to mention your fingers and eyes if your gun really blow up - and they can!
Again, as others have stated, it's really just best to choose a published and proven recipe.
Just my thoughts....