What's the rifle you're loading for? Is it a factory chamber and barrel, or a custom one? What kind of brass are you using?
For a friend's target rifle, we are loading 45.5 grains of H4895 into a Winchester case, a CCI BR primer (or a Federal 210), with a Sierra 155 seated to 2.805" (that's the first length I tried, it worked well, I haven't bothered trying to tweak it).
There's a good chance that you won't have to fuss much with the bullet seating depth, so save that for later. For now, just load to 2.800" (make up a dummy first, and just make sure that it isn't touching the rifling - if no rifling marks show up on your bullet, you're fine. If it is into the rifling, which is highly unlikely, you can go to 2.775").
Start low and work up. Nothing wrong with starting with the published starting load. It helps (greatly!) if you have a chronograph, and if you can also take your loading gear to the range. Prepare your sized and primed brass ahead of time, but throw your powder and seat your bullets at the range, as you need them. That way you just load what you need, as you need them, there's no need to preemptively predict what you might need to shoot.
I'd fire one shot at the starting load, then work up in 0.5 grain increments until you get to the published max; you're looking to see if pressure signs start to show (sticky bolt lift, cratered primers, all the usual).
If you have a 30" barrel, you should be able to get 2950-3025 fps before pressures start to show. Not quite sure what to expect for a 24" or 26" factory barrel (perhaps 2800-2850?)
Once you establish a range of powder charges that are safe, I'd try using one that is 0.5 grains below the highest charge you had that didn't show pressure signs (when I was loading for my friend's rifle, we got up to 46.0 without pressure signs; I went with 45.5 so that in case he is out shooting on a hot day there's at least a small bit of margin before pressures problems might crop up).
Load up five or ten rounds of this trial charge, and fire a group at 100 (ideally, chrono'ing as you fire the group). You're looking for small, round, consistent groups, with uniform velocity spreads. I fyou don't have rifle/scope/shooter problems, you ought to be able to fairly easily get to be shooting 5-shot groups that are reliably under an inch.
One thing about Sierra 155s, their tips are quite nonuniform. Don;t worry, this doesn't particularly matter. You may well see differences in seating depth (measured to the bullet tip) that varies .010" or even .015" from one round to the next. DON'T FIDDLE WITH YOUR SEATER ON A ROUND-BY-ROUND BASIS in an attempt to "fix" this, it isn't a problem. Your seater's stem contacts the bullet not on its tip, but on a ring some ways down the nose - this location is much more consistent w.r.t. the bullet's cylindrical portion (which is what engages the rifling). Just set up your seater to give you "typical" COAL readings of 2.800", and don't worry about apparent +/- .010" variations in COAL.