As Ben Hunchak and others point out, the 45-120 has a lot of capacity, which makes smokeless loads a problem. In general, a fellow should make sure that at least half the case is filled with powder once the bullet is seated, else you may experience highly erratic burning. Using IMR 3031 in a 45-90 load, with no filler, I got over 400 fps of extreme spread across my chronograph, for example. You can go with a real slow powder that will fill more of the case, but by the time you fill most of the 45-120 case, you may have a powder that burns so slow that you get poor burning, with a lot of trash left in the bore. You can also try to alleviate the problem by using a filler, but I would be very reluctant to try that in a 45-120 simply because it would be too much filler for me to guarantee that it would be safe. So, like the others recommend, the 45-120 is really a BP cartridge and I don't think a fellow should be messing around with smokeless in a BP cartridge with that much capacity. Smokeless in a 45-90 is bad enough (although I do have several smokeless loads that work well for the 45-90 if push comes to shove).