The only times I reach out past 100 yards with a 22 is when I'm shooting gophers out west, and we've reached well past 100 doing that. I'm reluctant to say 300 yards because the one spot we've really pushed it..I think it was easily past 300...but I don't remember if I ranged it. (photo below) I knew how high we were shooting over to get the POI where it needed to be, and how long it took CCI Blazer to get there...made me smile nearly everytime. lol That stuff is supposed to shoot a 40gr. bullet about 1235 fps or so, so on the faster side of things. It's an ammo type the gun likes, so no accuracy concerns...but I guess my point would be that I'd have nearly no faith in subsonic 22LR reaching those distances with consistent results. Where distance and wind is involved, things seem to start getting strange a bit past 100 yards...probably owing to velocity drop. (in part, at least) I wouldn't think reducing velocity would help with that.
Like most people, I let the gun choose the ammo it wants to shoot. For me, priority is accuracy...but every gun has a job, so I may only test ammo types best suited to the application. Gopher gun=needs the most accurate, fast, economical ammo. Target gun I seldom use, and only in fair weather=pricier, top-tier target ammo for punching tiny groups. Barn pigeon gun~something ultra low velocity/quiet...so CCI Quiet-22 gets the nod as shots are close, and there are usually animals close by. Pin-point accuracy not req. So, I try to get the ammo to fit both the gun AND application, but I always insist that the gun shoots it well...or I keep looking. At times, allot of my shooting sessions feel more like ammo-testing sessions...because even when I have something good going, I always want to know if a different ammo type (I haven't tried) will do better!
Longest distance I've ever shot gophers with the .22, plucking them off that distant hill top...or trying to.

Even aiming at the same spot, consecutive shots sometimes landed almost 2 feet apart due to wind gusts...so I punched more holes in the hill than I did in the gophers, but it was an absolute blast. Even hit one running! I was trying...but I'll call the hit more luck than anything else. lol I'm pretty good with the CZ 452 Varmint, but no miracle worker!