I know that when ever I am testing a series of different powders with the same bullet, the first bullet with a new powder, and sometimes the second hits out side the rest of the group. Not always,but the vast majority of the time. This happens to at least 80%+ of all rifles I have ever shot and reloaded for.
Example:
If I fire 5 shots with my favorite load for my 300WinMag. The group is about the normal size I expect to see. I then load 5 rounds into the magazine that has the same bullet, but a different powder type. The first shot, and sometimes the second will group together. But the next 3 rounds (shots 3,4,5) group in a slightly different location on the target. This second grouping is usually less than 1.5" away from the first shot or two. If I wait for the barrel to cool, I then shoot 5 more rounds at a different target with the same load to prove the group/load. Thats why I typically load 10 rounds for each test. I continue with this routine with all the test loads.
If I intend to shoot my favorite load again afterwards, the first one or two rounds of that load will also hit a different point of impact than it did just before I started testing the different powders. After these first one/two rounds the favorite load, it is printing where it is supposed to be on the target. The next series of groups I shoot after that with my favoite load averages in the normal grouping sizes.
This has been the trend I have noticed for close to 27 years of reloading/shooting. Many different types of rifles,many different calibers. Again I say that this happens the vast majority of the time, but not always.
Try it, and see if what I said is true for you.
I used to get frustrated when I would shoot a test load and always have it group poorly. Then if I had a few extra rounds left, i would shoot them off just to get rid of them and wind up with a good group all of a sudden.
My belief is that when ever you shoot a new powder in a barrel, it take one or two rounds to leave the characteristic fouling that is unique for that combination. Every subsequent round after that is encountering the same conditions round after round. The same thing seems to happen when you fire the first few rounds from a clean barrel. The subsequent rounds fire much more consistantly(velocity etc.).
Thats my .02, or .04, or uhhhh maybe .06 cents worth. LOL! Tell me what you think guys. I am open to other theories or ideas. Have fun and straight shoot'in!