I assume you are talking about talley lightweights, I have used them on a dozen rem/tikkas with success.
I only ever had 1 issue with talleys. Got a package that was mixed up 1 low and 1 medium, I should have known better, but when I tightened the screws, I got a dent.
I also believe that there is enough play in the screws to mis-align the front and rear lowers and cause an issue.
Now when I install a set I use a 1" or 30mm shaft. I mount the rings and loosen all the screws 1/4 turn. I mount the shaft in the lowers and install the top rings with 2 screws in each. The shaft will block the screw holes so you may have to loosen the top rings and shuffle it back and forth, but I will Loctite and tighten 1 screw in each mount with Loctite (the flange end of the talleys) and let the Loctite dry. Next day I install the other 2 screws and Loctite down. I use the blue/removable Loctite. A friend showed me that you can also out the lightest skim of Loctite under the lowers or on the receiver and that will take out some of the mis-alignment.