Several years ago an author, by the name of Sherman Bell, did an experiment in the Double Gun Journal.
He pressure tested some old large bore rifles. The big bore African elephant hunting (and poaching?) rifles. He put a strain guage on these guns and then ran a bunch of tests with different powders and bullets in the guns.
TrailBoss was good to go in any combination so long as the loads weren't compressed. If he compressed the powder, pressures would skyrocket.
I don't know what bullet you plan to use, but I don't think that TrailBoss would be a bad choice. It's bulky and expensive but you'll have a silly grin on your face after your first range session. I wouldn't try going to slow, just in case you stick a bullet in the bore...