Depends on the price and what you want to do with it. Are you looking to heavily modify it? If you find a beat up 10/22 that is dirt cheap, and all you are going to end up using is the receiver and bolt (if that), then it's worth it. If you're planning on keeping it stock and have to end up buying all sorts of bits and pieces, then perhaps buying a new one is the way to go. With the prices that 10/22's command, makes me wonder why it's worth it to buy used.