...The other thing that crossed my mind was that I did crack a new bottle of R22 although it has the same lot number....
Your old bottle of R22 had probably absorbed some moisture after the seal was broken making it heavier.
When you opened the new bottle of the same lot, the powder was drier and therefore when you weighed out the charge you got a bit more powder for the same weight, thus a slightly higher vel in spite of the colder temp.
This seems like a reasonable explanation to me.
This all goes to hell if the loading was all done by volume of course.
Re. the angle of the bullet through the chronograph: I don't think it's possible to get enough of an angle to cause error to be within the sensitivity range of the instrument. I don't think this would be a factor.