I'm going to chime in here. I have and use: N135, N140, N540, N150, N550, N160, N560, N165 & N170.
They are a bit more money, and that is the only downside.
The 100 series [single-base] rifle powders are clean, consistent and have good "manners" no silly pressure spikes or surprises.
The 500 series [double-base] are also very clean, consistent, and add energy for higher velocities at acceptable pressures.
I have found some superb applications with Vihtavuori powders [N165 in my 270 with the 140AB][N560 in my 260AI with Berger 140VLD][N140 in the 220 Swift with the 50BT]
One has to decide whether they can justify it themselves. I personally can.
Regards, Eagleye.