As said try a box of each and shoot the most accurate one. On game performance is about the same. My prefered bullet is the 50 Grain Sierra BK for 22-250. For some reason the BKs are very consistent in a whole bunch of rifles. They don't seem to show the same amount of rifle to rifle variation as Nosler.
I have 5, 22 hornets that I shoot exactly the same load in 12.6 of Lil'Gun, Fed Small Pistol primer, WW brass and a 40 grain Sierra BK. The best one groups these under 1/2 inch at 200 yards and the worst holds well under an inch at 200. Could never find any other bullet with this load where that held true across all five guns.