Yep.
As a matter of fact, just to remove error from the gun, when I go hunting, I always sight-in at the start of the season. I then clean the gun well, and then fire off one shot, just to make the barrel dirty. Then I hunt. That next shot I make will at a deer (hopefully), and I want it going nice and straight. I don't want it 2 inches high and to the right like my fouling shot might.