At what distance the bullet crosses your line of sight also depends on how high your line of sight is in relation to the bore. Using irons sights is completely different from a high mounted, large objective scope.
But more than just the cartridge ballistics, know the terrain that you will be shooting in... if you can't see past 100 yards there is not much point in a 200 yard zero... conversely if your shots historically have been 300+ yards you should maximize your point blank range. Plug your data into a ballistics calculator (like JBM) and input a 3" vital zone radius, and calculate for MPBR.
For example;
With the scope center at 1.5" above the bore, the Hornady 55 V-Max at 3200 fps with a 3" VZR, you would be 2.5" high at 100 yards, dead on at 248 yards and 4.1" low at 300 yards, the bullet will first cross the line of sight at 30 yards (not 50).