A shooter might want to consider using cast bullets for reduced loads in the .375 Mag., some cast bullets intended for the .38/55 will work well in the .375 with 4759 powder, M.T. Chambers makes many .376" designs including a 335 gr. Spitzer, 235 gr. F.P., 255gr. F.P., and 290gr. Paper Patch! Just make sure you don't try the Machine cast .379" bullets first, they are too big and are usually bevel base and lacking enough grease grooves, cast bullets have been tested to 2500fps. in .375 Mag. and show good results.