I have a Ruger Safari Magnum in .375H&H, and I like it. It has been to Africa with me and has accounted for 8 animals (7 species of game). It is reliable and consistently accurate for hunting purposes (1.25 MOA every time, every place, every day) with Remington premium ammo loaded with 300 gr Swift A-Frames.
My only complaint is that it is fairly heavy. With scope it weighs in at 10 lbs. On the other hand the extra weight helps moderate recoil in what otherwise is a fairly stout cartridge.
Here are a couple of pics