Chuck,
I've got a few of these, Leupold Varminter, B&C, and the plain Jane Leupold LR. The one that gets the most use is the B&C on my Kimber 22/250.
Something you have to decide is how close is close enough. 3/4s of big game rifle owners will sight in 3 inches high at 100 believeing that plus or minus 3 inches out to 300 yards doesn't mean ####. By that measure, if your bullets are landing within 3 inches of the holdover lines you are just as good as the MPBR method.
There's more that you can do to fine tune though. The subtension of the reticle changes with the power setting of your variable scope. The easiest quick and dirty method is to sight in at 200 then go straight to 400 and shoot a group still useing the main crosshairs. Mark the 400 yard group with something visible, then go back to your firing point and crank the variable knob back and forth until the main crosshairs are on the target center and the 400 are sitting on your marked 400 yard group. Now that 200 and 400 are taken care of, 300 and 450 will take care of themselves at that power setting. Past that, you may be happier twisting turrets.
The guy who sights in at 100, guesses what it'll take to be on at at 200, then expects the magic crosshair to make him a 600 yard shooter is kidding himself. Play with them a bit and fairly good work can be done. My 22/250 has shot truckloads of quarter mile coyotes, using the 450 line at the suggested 14.5 power. The 6.5-20 on my .223 needs to be set at 14 power to hit gophers out to where I have trouble seeing them. My STW needs the power set at 14.5 to track my 140 loads, but honestly a 300 yard sightin with the main crosshairs and a center hold takes care of zero to 400 rather nicely all by itself. The 200 and 300 yard crosshairs take care of my .375 H&H and 270 grain loads rather nicely at 10 power. I don't see any need for it past that so haven't checked.