I was faced with a similar question when I was trying to decide on a light weight rifle for hiking around in the Yukon. I wanted more than the .30/06 could produce, but without the recoil that something like a .375 Ultra would produce in a light rifle. I hummed and hawed, first about short cartridges like the .350 Magnum, the .35-284, and the .375-284, and finally opted for a long action cartridge, initially a 9.3X62, which was then switched up to a .375 Scovile/Hawk when I discovered that Ron Smith couldn't give me a .366 barrel, and I'd have rather given up the 9.3 than the Ron Smith barrel. Anyway, the thing has since morphed into a light weight switch barrel with additional barrels in .243 and .280 Ackley, now I'm in the waiting mode until its finished up and shipped.