Its tough to say how many failures I've had; partly because I don't rate success or failure by what a bullet looks like, or what it weighs, only by what it does. What it did can be weighed against what it was supposed to do.
I think I've heard the Warren Page quote one friggen time too many. As quaint as it is, it does presuppose that the bullet actually did kill the animal. Many animals are killed with a second shot, or by someone else.
A few notable failures that I had could be put down to misapplication. 40 V-max exploding on coyotes making a wound a foot wide and an 1/2" deep. I thought that maybe the 22/250 was driving them too fast so I tried them in a .223. That one proved to be an education in misapplication. I called a coyote to the edge of a coulie and smacked it in the ribs. With the heavy barrel Remington, bipod and 24 power scope it was easy to watch the bullets hit. Bang, whack get up, bang whack down and back up. Every time it got back up it would struggle/ roll down the slope a little farther. I shot the gun dry twice on that one. So at what point did those ones fail? I'm going with pretty much the entire time between shots 1 and 8, but will admit that it was a misapplication. Oddly enough plenty of people swear by them.
In the early 90's, about 4 component crisises ago I caught a nice whitetail buck in the open at the same time as I was caught with a mag full of Speers in a 7mm STW. Shooting from a bipod from prone it was easy to hit that buck, but I knew I was in trouble from the first shot. I could see the hair flying and shots hitting and my partner was confirming that every shot was hitting. Seems I shot the gun dry twice on that one too. The deer was full of exploded bullets, and one which I found interesting was bent like a banana and stripped of its jacket. For a short blip in history those bullets were available as factory loads so I don't entirely believe that I own that misapplication. Messy as it is, when caught in a bad situation there is little you can do but keep shooting.
A 190 Berger VLD blew up on a 440 yard whitetail buck, not making it through the ribs. My son shot that one for me with a .257 Weatherby with a 100 grain Ballistic Tip at 30 yards. His bullet exited; the irony of that still rankles. Was that a mis-application? Not according to Berger and every hunter with a TV. I disagree.
The most recent spectacular failures I had involved a moderately sized water buffalo, a borrowed VC .450 NE double and Hornady factory DGX loads. I'm not taking the blame for that one after Verny Caron regulated the $13,000 rifle for them and Hornady both called the bullets Dangerous Game Expanding and drew a picture of a buffalo on the box. I had a dead buffalo in the time it took to say boom,boom.....boom, boom.......boom damnit headshot, boom. I'd say that those bullets failed somewhere in the 5-6" that they penetrated and blew up, but to answer Warren Page it was pretty much throughout the entire death. Some day Hornady will learn to make a dangerous game bullet but I'm not holding my breath. They could have copied one by now.
I had a 400 Grain .416 TSX make a 90 degree turn in a cape buffalo. I'm counting that as a failure too, that lasted until we got a couple of solids into the other shoulder.
Hunted with a Detroit gent in Zim who was using a .378 Weatherby and factory ammo. I don't know whether he got the 300 grain Hornadys in the wrong box, or if Norma did it for him. All I know for sure is that they weren't the 300 grain Partitions that he thought they were and that he shot a huge eland bull from morning to evening when he ran out of shells and killed it with a .416. I may have swapped rifles a little sooner myself, but that doesn't change that the eland had 13 holes in it when the fat lady sang. More exploding bullets.
Theres others, but that will do for now.