I shoot a 22-250 and am not a hand loader. I weighed in on both when I made my purchase and came to the following conclusions:
1: I don't shoot much with them at the range.....just to get them lined up for hunting.
2: Trajectory.....the 22.250 is flatter shooting.
3: The 223 due to the rate of drop after 300 yards IMO makes it a 300 yard coyote rifle. The 22.250 adds another 100 beyond that comftorably.
4: Factory hunting rounds are about only $1/box difference in price on the better ammo and about $2/box on the econo packs.(Hunting rounds.... I am not talking about those surplus FMJ rounds)
5: Most important......I just plain like it better!!
As for fur friendly? I shoot 45gr and 50gr JHP and the 45's do not even make an exit hole at 100 yards and the exit hole from the 50 grainers I have used have been about the size of a pencil eraser.