Note, some combos of slow burning powder actually extend bore life. There are several 6mm wildcats built around this concept and their results seem to show promise.
The 22-250/90gr is NOT a fussy set up. Mostly because you have tons of case volume to motivate the bullet to its prefered operating speed. I have built a few and they are lots of fun.
Long bore life? Of course not. But neither is the orig 22-250 shooting 55gr bullets... at least that depends on what your accuracy goals are.
If you want the ballistics of a 300WM with zero recoil, this works very nicely. AND bore life is similar so....
I am currently playing with the 6XC and having alot of fun. Accurate and easy to tune. Will it wear before a 6BR? more then likely but going up to 200fps faster has its advantages.
Bore life discussions are a murky debate at best. What is accuracy to each shooter? How will the barrel be shot? How hot will it get? and so forth.
I go by a simple rule of thumb as it seems to play well across all cals. Push a heavy for cal, high BC/low drag bullet around 3000fps, and you are likely to see 1/2 min accuracy into the mid teens (1500rds). Keep it cool or slow rate of fire, maybe get into the high teens/low 2's.
Run this combo fast and very hot, 800 to 1200rds is about it.
Take this combo and drop 100fps, bore life goes up about 20%. Drop another 100fps and it goes up about 50%. Drop another 100fps and you will easily double lifespan - there are very good reasons why most military cartridges of the past ran their bullets around 2600/2700fps.
It takes a whole lot of energy for each 100fps you want to go faster and that greatly reduces bore life. Playing around with powders and barrel lengths can muck with the results so again, depends on what you are discussing.
YMMV
Jerry