The .460 Weatherby with a 350 gr TSX would have the velocity to be a reasonably flat shooter, and would then arguably be useful as a single rifle for all your African shooting. The problem is that if you put anything but a low power scope on this thing, since eye relief diminishes with magnification, one of two things will happen; either the scope will be mounted too close to your eyebrow, and you'll get cut like never before, or if mounted correctly, as you increase the magnification much above 3X, the image in the scope will begin to doughnut, making higher magnifications unusable.
The primary purpose of an optical sight is not magnification, its that the aiming point and target are in simultaneous focus. When I was shooting my .375 Ultra with it's low power scout scopes, first the Burris Scout, and later a Leupold EER, I could easily hit game sized targets out to 400 yards. When I was shooting my .416 Rigby, I mounted a 1.5-5X Leupold to a custom quarter-rib, so the ocular was even of the face of the falling block. Mounted in this manner, I could use the scope up to 3X, and again, shots out to 400 yards were not a problem on targets that contrasted sharply with their surroundings. The difficulty that occurs with any low power glass is that when your target appears at a longish range, if the target's color blends into the background, and its silhouette is broken up by vegetation, it is then difficult distinguish from it's background. If on a bright day your target stands in a shadow against a dark background, it will b e difficult to see. In all other circumstances the low power scope has the advantage of brightness, field of view, and speed of acquiring and tracking a live target, across any typical big game hunting range.
My recommendation is the excellent 1-4X Nightforce. Long eye relief, an adjustable illuminated reticle, and a 30mm tube are it's primary features. Like any variable power scope, the disadvantage is the challenge of mounting the scope far enough forward due to the long ocular housing. I think you'll find that a one piece Picatinny rail provides the greatest latitude for getting a variable power scope positioned correctly on a bolt action rifle. This scope is no lightweight, but a little extra weight does no harm on a big Weatherby.