Certainly can - and you can go lower than that. I shoot 3.3 - 3.6gr N310 with 230gr LTC's in the .45, at ~620 fps. No reason you couldn't get right down to wadcutter-speed if you wanted; remember, the initial .45 load was 230r hardball with Bullseye, ~850 fps. That's why I like small amounts of fast powder for big cases like .45 ACP (or say, .44 magnum) - more likelihood the stuff will actually generate enough heat / pressure to burn.
I shot-off ~40 rounds of .45 ACP loads that I'd loaded too light, out of my .455. These were 3.2 / 3.4gr Win 231, they were so soft they wouldn't work the actions on the .45's. So sooner than pull the bullets, I shot 'em off in the revolver. Well, they were loaded with 200r LSWC's - and you can't crimp .45 ACP, it headspaces on the rim. So, not much powder, leaking pressure through the flash gap and and little impediment from that little uncrimped bullet - these things came out like it was raining; sprays of unburned / partially burned powder out the muzzle. To shoot 'em clean in the .45's, I ended-up laddering up to 4.2gr; they shot well and cycled the actions at 3.6gr, but made a dismal, hard-to-clean mess of the guns.
Surf teh interwebz, lots of good part-loaddata. And I recommend you consider Trail Boss; it's more-or-less tailored for what you're doing.