I've used 22 250 for many deer with many types of loads from 35 grain v max at 4200 fps to 55 grain sp at more reasonable speeds.
One mistake that I see above is the assumption that a heavier bullet is better. This is not true for this reason. A heavier bullet goes slower. Therefore, when we think that a heavier bullet is better, we must admit that we are really saying that we need a slower bullet with the same energy. The value of a tiny bullet going quickly is the way that it can give up it's energy in an extremely short distance. The energy can go into rib bones and into creating a shock wave through the organs that the heavy slow bullet could never hope to.
Therefore, don't take a 22 250 and put a heavy, slow moving lead into it and turn it into a poor excuse for a 30 30 by slowing it down and rubbing off it's energy over a foot-long path through the organs. If anything, lighten it up and speed it up until it hits and dumps all of it's energy in the first couple of inches - into ribs that receive that energy so that they go through the lungs and heart like shrapnel.
If it hits high in the shoulder, it dumps its load of energy into the blade and this sends a shock wave into the spine, putting the deer down for the walk-up shot. ( This isn't the ideal shot, but if this is what happens, it still leads to venison.)
If the shot is a correct fore and aft, but a little high, the same thing happens - the spine gets the shock wave from ribs and the deer is down but not dead.
One strange advantage to the tiny explosive bullet is that it does not carry on through after it hits. If the shot is a quartering shot, don't aim for the centre of the deer like you might with a 270, but aim at the same spot just behind the near side leg. ( It is nice if you can discuss this with the deer and get him to put the near leg forward while you shoot.) When the bullet hits the ribs just outside the lungs, the bullet gives up all of it's energy - which blows those ribs into the lungs and heart and major arteries - and the bullet travel is done - not going on ( remember that this was a quartering shot) through the guts or far shoulder ( depending on which way it is quartering.)
I don't shoot bouncy deer with a 22 250.
I've used 40 grain HP. No problem.
The 35gr Vmax was the most notable - meant for a 22 Hornet - it broke three ribs on the way in - direct broadside - and the lungs were mush.
If you are going to use a little bullet, use it well, and you will save venison - use it badly and you will not quickly forget the sick feeling of not finding a deer that you know is hit. Every old hunter has memories - the wretched feeling of having spent your whole day looking for a deer that someone didn't hit well.
I spent a whole day looking for a deer that a guy said that he shot ( it was a very special deer that we knew well - with antlers that were very very tall and narrow) - said he shot it with a 7mm at 100 yards. I went to see what happened and found where he had shot - out his truck window from the centre of the road - about 35 yards tops - and the happy ending is that a few days later, we had new pics of him on our trail camera. The reason I tell this is to illustrate that it is not the size of the bullet, but the good honest shot. Don't ever take a shot in optimism or that you might have to make an excuse to cover.
Some guys get excited when it comes time to shoot - if this is you, use a 243 or more - and try to learn to stay calm I guess. Some go chill and still.