What 500gr cast bullet? Different bullets, different recipe's. .457 or .458 or larger? Pure lead or slightly hardened? Have you checked the powder manufacture website.
Fun shooting, scroll down to 45/70, 500gr. http://www.gmdr.com/lever/lowveldata.htm
Stevespages.com H-4198 From 25.0 grains to 41.0 grains for a 500 grain bullet. Start low, watch for pressure signs.
If you're referring to "pressure signs" on the brass, the problem with that old maxim is that pressure signs are notoriously deceptive in any event, and will only show up on brass at pressures well above what most rifles chambered for 45-70 can safely stand. A worse case example of this is when someone with an old pistol designed for 15K psi thinks that they can depend on the brass to tell them the pressure is too high - however, the first "pressure sign" they'll encounter is a damaged gun.
If the "pressure signs" are MV's, then you're much better off.
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