Ive been reading about loading .45 for a carbines and I'm learning that fast .45 powders don't give as much improvement in velocity in carbine length barrels as say a .357 would. A slower pistol powder would be better to keep max pressure low and get superior velocity, but then your ammo is optimized for Carbine not 4" pistol barrels.
So yes, to get them all the way out you'll need to start with a higher minimum and need to work closley to factory ammo. Semi auto designs have less tolerance for variance in ammo than other design like bolts and going from semi pistol to semi carbine only lowers the tolerance on the low end.