I never neck size only hunting ammo. I like to neck size when I can because I can do it without lubricating the case. It also gives me peak accuracy so I can figure out what loads are working best and see how the gun shoots when all ammo variables are neutralised.
I do neck size varmint loads, and based on that I would say that if you shoot loads that aren't crazy hot, and use for hunting only those cases that have been fire formed just once and then neck sized, you probably won't have a problem. I always seat a fraction back from the rifling, however, depending on the shape of particular bullets, their weight, and the quality of chamber cut in the gun that can sometimes be too loose also.
"My ammo generally shoots a bit better than MOA, and while confidence building, this is far more accuracy than I can manage from field positions other than prone"
Right, but the inaccuraccy is cumulative. If you can only hold 1 MOA in prone, say, and your rifle is 1 MOA, then you will be shooting 2 MOA on targets. That's 5 inches at 250 yards before factoring any other possible source of inaccuraccy, of which there are many. If your ammo was capable of .5 MOA, then your groups would shrink to 3.75" for no reason other than a better load. Often gun writers use the phrase "but that is more accurate than I can shoot", seeming to imply that if the gun shoots 1" groups and the shooter holds 3 MOA, then the overall effect will be 3" groups on target. Not true, inaccuracy always costs. I'm sure you know this, just nailed one of my buttons (good shooting!

).
I do think a lot of these tricks were not intended for the hunting fields, they normally work best with target cut chambers which one rarely finds in factory rifles, let alone Lee Enfields. But it is the kind of thing where one can do the experiment and see what happens.