I have a 45-90 and have tinkered with loads quite a bit. My loads are all recoil limited as once you get above 400 gr bullets even at - watch out!
What rifle is it chambered in? You can use full cases of powders slower than Varget even up to 500 gr in any action - even "Trapdoor" strength. Go with a stronger action and you can walk the powders suitable for a full case with a 500 gr (and lighter) bullet back a bit to powders faster than IMR-4064.
If you work with a 4350 and slower, you won't exceed safe pressure limits, with any weight bullet up to 500 grs, in any action.
Two of my favourites: H4831 and US869 - both with magnum primers.