If you're hand loading, you might consider 45-70 as you can download it a lot as well as hot load. Very versatile, especially if you get into casting. Alternatively you could go the 45 colt route as you can hot load it fairly well in a modern 1892 action as well as have ultra light plinkers. Same goes for 44 mag and 357 mag. If you want off the shelf ammo availability, 30-30 would be probably the best for what you're asking.
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