Is it possible for one rifle that shot larger groups at 100 yards to shoot better at 200 yards (MOA-wise) than another rifle that shoots smaller groups at 100 yards?
If it is, what would explain such a situation?
I agree, I needlessly added details which seem to have confused my point.
Let me be more clear.
Rifle A is a 22LR rifle that shoots 0.1MOA groups at 50m every single time using the best benchrest ammos available.
Rifle B is a centerfire rifle that shoots 1.0 MOA groups at 50m every single time using the highest BC heaviest for caliber bullets available.
To make it more clear - let's spread our distances apart even more and ask a simple question.
Given the two rifles, which rifle would be predicted to produce the smaller group at 600m?
If you can with a straight face suggest the 22lr has a chance, this isn't a conversation being had in good faith and not worth continuing.
If you agree with the obvious, the answer to your question
Is it possible for one rifle that shot larger groups at 100 yards to shoot better at 200 yards (MOA-wise) than another rifle that shoots smaller groups at 100 yards? is very clearly
YES .
To answer the second part if your question -
what would explain such a situation? is clear to anyone who shoots at any sort of distance. Balistically (is that even a word?), the centerfire bullet is superior to the smaller rimfire one. It has a higher BC bullet that is traveling faster, thus it does a far better job at minimizing the effects of the environment over longer distances. The fact that is is 0.9 MOA less accurate at close range is overshadowed by the fact that it is multitudes better at reducing the effects on it while in flight over long range.
Everything else you have said is just an attempt to muddy the waters to argue against pure fact. The extreme comparisons are needed to show a basic truth. If you can agree to the obvious conclusions of the extreme comparisons, it would be rational to make the leap that it is still fact in less extreme comparisons, though much harder to see the differences.
The only thing in question right now is at what point are we at. Are we at a point where the increases in BC in a newer and less consistent design is worth giving up the tried and true consistency of the best match grade ammunition? Possibly not yet.
Would long range guys give up a little bit of consistent accuracy for massive reductions in environmental effects on trajectory? Probably.
You end by mentioning lot testing the same old ammos for maximum benefit at long range. Again - this isn't about finding the best of the current offerings and making it do something it wasn't designed to do. This is about designing something new with properties that are beneficial to shooting longer, even if that means giving up some advantages for closer range.