The 22-250 is a fine cartridge, I have owned several. But it is a legitimized wildcat, and should be treated like a wildcat. You can get into trouble real quick, sometimes.
And not every rifle can handle top loads. My advice, try a box of factory first. That will let you know if the rifle is ordinary, or an exception. The throats burn out in the 22-250 fairly quickly, and when the throat is a bit torched, it will handle a bit more powder than would be safe in another rifle.
It's been my experience that W-W 760 or Hodgdon 414, (same powder), is not temperature stable enough for my liking. I'd advise against using it.
I've attached a few photos of a 22-250 throat, typical of what you'd find in a used 22-250. Your rifle is new, if you try loads that work good in a rifle with a throat that is eroded, the pressures may be excessive in a new gun.
For the record, H380 was an unnamed surplus powder that Hodgdon had a bunch of. Bruce was trying it in his 22-250, and with 38 grains of powder behind a 55 grain bullet he got some pretty good groups. So he named it H380. At least that is what I've read.